With a total surface of about 1.8 m² and a total weight of about 11 kg, our skin is the largest human organ. It does not just only give us our appearance and shape, it also serves other important functions like protection from mechanical, thermal, environmental impact, and regulation of body temperature. It has three layers: the epidermis, dermis, and subcutaneous layer. Stratum corneum is the most important layer of epidermis; it contains mainly the following lipids (ceramides, fatty acids, and cholesterol) Dry skin (xeroderma) occurs when natural moisture is drawn out of the skin due to barrier defects. The barrier defects result from losing the intercellular lipids that lead to a phenomenon known as transepidermal water loss. The excessive water loss from the skin surface produces dryness, known as xerosis.